histone H1.0; histone H1(0); histone H1' (H1F0 H1FV)

Function

• histone H1, necessary for the condensation of nucleosome chains into higher order structures
• phosphorylated upon DNA damage, probably by ATM or ATR
• phosphorylated on Ser-17 in RNA edited version

Structure

belongs to the histone H1/H5 family

Compartment

• nucleus
• RNA edited version localized to nuclear speckles; during mitosis, it appears in the vicinity of condensed chromosomes

RNA editing

• partially edited
• in ~3.6% of the mRNA molecules, a new initiator Met is created by a single uridine insertion in the 5'-UTR, causing an N-terminal extension of 99 amino acids
• the RNA edited version is called ET-H1.0

Expression

• expressed in cells in terminal stages of differentiation or with low rates of cell division
• both the unedited & the RNA edited versions are induced by butyrate (at protein level)
• only RNA edited version is induced by DTT, vinblastine or TNF (at protein level)

More general terms

• histone-H1

Database

• UniProt: http://www.uniprot.org/uniprot/P07305.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3005
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3005
• OMIM: https://mirror.omim.org/entry/142708