zinc finger & BTB domain-containing protein 23; zinc finger protein 336; GDNF-inducible zinc finger protein 1 (GZF1, ZBTB23, ZNF336)

Function

• transcriptional repressor
• binds the GZF1 responsive element (GRE) (consensus: 5'-TGCGCN[TG][CA]TATA-3')
• may be regulating VSX2/HOX10 expression
• interacts with NCL

Structure

• belongs to the krueppel C2H2-type Zn+2-finger protein family
• contains 1 BTB/POZ domain
• contains 10 C2H2-type Zn+2 fingers

Compartment

• nucleus, nucleoplasm, nucleolus
• nuclear localization depends upon NCL

Expression

• expressed in adult brain, heart, skeletal muscle, kidney & liver
• also detected in fetal brain & kidney
• expressed at lower levels in fetal lung & liver
• induced by GDNF

More general terms

• Zinc finger & BTB domain containing protein
• transcriptional silencer (transcriptional repressor)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=64412
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:64412
• OMIM: https://mirror.omim.org/entry/613842
• UniProt: http://www.uniprot.org/uniprot/Q9H116.html