homeobox protein-10; HOX-10; C. elegans ceh-10 homeo domain-containing homolog (VSX2, CHX10, HOX10)

Function

• role in the specification & morphogenesis of the sensory retin
• may also participate in development of the cells of the retinal inner nuclear layer, particularly bipolar cells (putative)

Structure

• belongs to the paired homeobox family
• contains 1 CVC domain
• contains 1 homeobox DNA-binding domain
• contains 1 OAR domain

Compartment

nucleus

Expression

• abundantly expressed in retinal neuroblasts during eye development & in the inner nuclear layer of the adult retina; within this layer, expression is stronger in the outer margin where bipolar cells predominate

Pathology

• defects in VSX2 are the cause of
  • microphthalmia with cataracts & iris abnormalities
  • isolated microphthalmia with coloboma 3
  • isolated microphthalmia 2

More general terms

• homeobox protein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3389
• OMIM: https://mirror.omim.org/entry/142993
• UniProt: http://www.uniprot.org/uniprot/P58304.html