Rho guanine nucleotide exchange factor 15; ephexin-5; E5; Vsm-RhoGEF (ARHGEF15, KIAA0915)

Function

• specific GEF for RhoA activation
• does not activate RAC1 or CDC42
• regulates vascular smooth muscle contractility
• negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2
• phosphorylated on Tyr upon EFNA1 stimulation EPHB2-dependent phosphorylation at Tyr-353 triggers UBE3A-mediated ubiquitination (putative)
• ubiquitinated; UBE3A-mediated ubiquitination & degradation by the proteasome promotes EFNB1-dependent synapse formation
• interacts with EPHB2 (putative)
• interacts with EPHA4

Structure

contains 1 DH (DBL-homology) domain

Compartment

• cell projection, dendrite (putative)

Expression

• dendrites of the developing hippocampus (putative)
• expressed in the vascular smooth muscle of coronary artery
• seems to be some confusion here (see UniProt)

More general terms

• rho guanine nucleotide exchange factor
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=22899
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:22899
• OMIM: https://mirror.omim.org/entry/608504
• UniProt: http://www.uniprot.org/uniprot/O94989.html