Rho guanine nucleotide exchange factor 11; PDZ-RhoGEF (ARHGEF11, KIAA0380)

Function

• may play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) & guanine nucleotide-binding alpha-13 (GNA13)
• acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase & may act as GTPase-activating protein (GAP) for GNA12 & GNA13
• interacts with GNA12 & GNA13 through the RGS domain
• interacts with RHOA, PLXNB1 & PLXNB2
• interacts with SLC1A6

Structure

• the poly-Pro region is essential for plasma membrane localization upon stimulation
• contains 1 DH (DBL-homology) domain
• contains 1 PDZ domain (DHR domain)
• contains 1 PH domain
• contains 1 RGSL (RGS-like) domain

Compartment

• cytoplasm, membrane
• translocated to the membrane upon stimulation

Expression

ubiquitously expressed

More general terms

• rho guanine nucleotide exchange factor
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9826
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9826
• OMIM: https://mirror.omim.org/entry/605708
• UniProt: http://www.uniprot.org/uniprot/O15085.html