plexin-B2; MM1 (PLXNB2 KIAA0315)

Function

• receptor for SEMA4D
• plays a role in RHOA activation & subsequent changes of the actin cytoskeleton
• plays a role in axon guidance, invasive growth & cell migration
• binds c-MET, ARHGEF11 & ARHGEF12
• may also interact with MST1R

Structure

• monomer, & heterodimer with PLXNB1
• belongs to the plexin family
• contains 3 IPT/TIG domains
• contains 1 Sema domain

Compartment

membrane

More general terms

• plexin B
• glycoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2365
• OMIM: https://mirror.omim.org/entry/604293
• UniProt: http://www.uniprot.org/uniprot/O15031.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23654