semaphorin-4D; BB18; A8; GR3; CD100 (SEMA4D, CD100, SEMAJ)

Function

• may play functional role in immune system & nervous system
• induces B cell aggregation
• binds plexin B1

Structure

• belongs to the semaphorin family
• contains 1 Ig-like C2-type domain (immunoglobulin-like)
• contains 1 PSI domain
• contains 1 sema domain

Compartment

• membrane; single-pass type 1 membrane protein

Expression

• expressed in skeletal muscle, spleen, thymus, peripheral blood lymphocytes > testes, brain, kidney, small intestine, prostate, heart, placenta, lung, pancreas
• not expressed in colon, liver, immature bone marrow cells

More general terms

• CD antigen
• membrane protein
• glycoprotein
• semaphorin or semaphorin/collapsin family protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10507
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10507
• OMIM: https://mirror.omim.org/entry/601866
• UniProt: http://www.uniprot.org/uniprot/Q92854.html