aryl hydrocarbon receptor nuclear translocator-like protein 2 (brain & muscle ARNT-like 2, member of PAS protein 9, basic-helix-loop-helix-PAS protein MOP9, CYCLE-like factor, CLIF, ARNTL2, BMAL2, CLIF, MOP9)

Function

• interacts directly with CLOCK to form BMAL2-CLOCK transactivator
• BMAL2-CLOCK heterodimers activate E-box element (3'- CACGTG-5') transcription
• in umbilical vein endothelial cells, activates SERPINE1 through E-box sites, this transactivation is inhibited by PER2 & CRY1.
• component of the circadian core oscillator
• iinteracts with NPAS2, HIF1A

Structure

• contains 1 basic helix-loop-helix domain (bHLH)
• contains 1 PAC domain (PAS-associated C-terminal)
• contains 2 PAS domains (PER-ARNT-SIM) Commpartment: nucleus

Alternative splicing

named isoforms=8

Expression

• expressed in fetal brain
• expressed in brain & placenta
• lower levels in heart, liver, thymus, kidney, lung
• expressed in endothelial cells & neuronal cells of the suprachiasmatic nucleus
• detected in endothelial cells of the heart, lung & kidney
• in the brain, specifically expressed in the thalamus, hippocampus & amygdala
• constitutively expressed
• no circadian rhythm expression pattern

More general terms

• DNA-binding protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q8WYA1.html