neuronal PAS domain-containing protein 2 (neuronal PAS2, member of PAS protein 4, basic-helix-loop-helix-PAS protein MOP4, NPAS2, MOP4)

Function

• BMAL1-NPAS2 heterodimers activate E-box element (3'-CACGTG-5') transcription of a number of proteins of the circadian clock
  • transcription is inhibited in a feedback loop by PER & by CRY proteins
• component of the circadian clock oscillator
• efficient DNA binding requires dimerization with another bHLH protein
• heterodimerization with CLOCK or NPAS2 is required for E-box-dependent transactivation.

Compartment

nucleus Polymorphims:

• variants in NPAS2 show a susceptibility to seasonal affective disorder

More general terms

• DNA-binding protein

Component of

• circadian clock oscillator

Database

• OMIM: https://mirror.omim.org/entry/603347
• OMIM: https://mirror.omim.org/entry/608516
• UniProt: http://www.uniprot.org/uniprot/Q99743.html