SON protein; SON3; negative regulatory element-binding protein; NRE-binding protein; DBP-5; Bax antagonist selected in saccharomyces 1; BASS1 (SON C21orf50 DBP5 KIAA1019 NREBP)

Function

• represses hepatitis B virus (HBV) core promoter activity & transcription of HBV genes & production of HBV virions
• binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3'
• might protect cells from apoptosis
• might be involved in pre-mRNA splicing (putative)

Structure

• contains 8 types of repeats which are distributed in 3 regions
• contains 1 DRBM domain (double-stranded RNA-binding)
• contains 1 G-patch domain

Compartment

• nucleus speckle
• colocalizes with the pre-mRNA splicing factor SFRS2/SC-35

Alternative splicing

named isoforms=10

some isoform(s) may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

Expression

• widely expressed, with the higher expression seen in leukocytes & heart

More general terms

• DNA-binding protein
• phosphoprotein

Database

• UniProt: http://www.uniprot.org/uniprot/P18583.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6651
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6651
• OMIM: https://mirror.omim.org/entry/182465