deleted in azoospermia protein 3 (DAZ3)
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Function
- RNA-binding protein
- role in spermatogenesis
- binds to 3'UTR of mRNAs & regulates their translation
- forms a heterodimer with BOLL & DAZL
- interacts with PUM2, DAZAP1, DAZAP2, DZIP1 & DZIP3
Structure
- belongs to the RNP DAZ family
- contains 12 DAZ-like domains
- contains 1 RRM domains (RNA recognition motif domains)
Compartment
- cytoplasm, nucleus
- predominantly cytoplasmic
- nuclear at some stages of spermatozoide development
- localizes both to nuclei & cytoplasm of spermatozoide
- nuclear in fetal gonocytes & in spermatogonia
- relocates to the cytoplasm during male meiosis
Expression
testis specific
Pathology
- AZFc deletions in the Yq11.23 region, including the DAZ genes, are a cause of azoospermia or oligospermia
Polymorphism
- number as well as the precise structure of DAZ proteins differs within population