pumilio homolog 2 (pumilio-2, PUM2, KIAA0235, PUMH2)
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Function
- sequence-specific RNA-binding protein
- regulates translation & mRNA stability by binding the 3' untranslated regions (UTRs) of mRNA targets
- role in proliferation & self-renewal of stem cells by regulating translation of key transcripts (putative)
- interacts with DAZ, DAZL & NANOS1 via its pumilio repeats
- binds to RNA consensus sequence, related to Nanos Response Element (NRE), a 16 bp sequence found in the 3'UTR of the Drosophila hb mRNA
- binds to the NRE
Structure
- homodimer
- contains 8 pumilio repeats
- the pumilio repeats mediate the association with RNA by packing together to form a right-handed superhelix that approximates a half donut
- the number as well as the specific sequence of the pumilio repeats determine the specificity for target mRNAs
- contains 1 PUM-HD domain
Compartment
Alternative splicing
named isoforms=3
Expression
- expressed in testis, ovary, stem cells, germ cells > brain, heart, kidney, liver, muscle, placenta, intestine, stomach
- expressed in cerebellum, corpus callosum, caudate nucleus, hippocampus, medulla oblongata, putamen.
- expressed in all fetal tissues
- dwn-regulated in keratinocytes upon UV B radiation