deleted in azoospermia-like (DAZ-like autosomal, deleted in azoospermia-like 1, DAZ homolog, SPGY-like-autosomal, DAZL, DAZH, DAZL, DAZLA, SPGYLA)

Function

• RNA-binding protein
• essential for gametogenesi
• role iin spermatogenesis
• binds 3'UTR of mRNA & regulates translation of key transcripts (putative)
• forms heterodimer with DAZ
• interacts with BOLL, DAZAP1, DAZAP2, PUM2
  • DAZ-like domain mediates interaction with DAZAP1, DAZAP2

Structure

• homodimer & heterodimer with DAZ
• belongs to the RNP DAZ family
• contains 1 DAZ-like domain contains 1 RRM domain (RNA recognition motif)

Compartment

• cytoplasm, nucleus, predominantly cytoplasmic
• nuclear in spermatogonia until near the end of meiotic prophase, cytoplasmic then onward

Expression

testis specific

Pathology

• defects in DAZL may be a cause of infertility due to oligozoospermia & non obstructive azoospermia

More general terms

• RNA-binding protein

Additional terms

• DAZ protein (deleted in azoospermia protein)

Database

• OMIM: https://mirror.omim.org/entry/601486
• UniProt: http://www.uniprot.org/uniprot/Q92904.html