DAZ-associated protein 1 (deleted in azoospermia-associated protein 1, DAZAP1)

Function

• RNA-binding protein may be required during spermatogenesis
• interacts with DAZ & DAZ

Structure

• contains 2 RRM domain (RNA recognition motif)

Compartment

• cytoplasm, nucleus, predominantly cytoplasmic
• nuclear at some stages of spermatozoides development
• in midpachytene spermatocytes, localized in both cytoplasm & nuclei, excluded from the sex vesicles
• in round spermatids, it localizes mainly in the nuclei
• in elongated spermatids, it localizes to the cytoplasm

Alternative splicing

named isoforms=2

Expression

• largely expressed in testis
• expressed to a lower level in thymus
• weakly or not expressed in heart, liver, brain, placenta, lung, skeletal muscle, kidney & pancreas

More general terms

• RNA-binding protein

Database

• OMIM: https://mirror.omim.org/entry/607430
• UniProt: http://www.uniprot.org/uniprot/Q96EP5.html