nanos homolog 1 (NOS-1, EC-Rep1a, NANOS1, NOS1)

Function

• regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3' untranslated regions of mRNA targets

Structure

• belongs to the nanos family
• contains 1 nanos-type zinc finger
  • essential for translation repression activity

Compartment

cytoplasm, perinuclear region

Expression

• predominantly expressed in testis
• specifically expressed during germline development
• in adult tissues, mainly expressed in spermatogonia
• also expressed during meiosis in spermatocytes
• expressed in fetal ovaries
• weakly or not expressed in mature postmeiotic oocytes

More general terms

• zinc finger protein

Database

• OMIM: https://mirror.omim.org/entry/608226
• UniProt: http://www.uniprot.org/uniprot/Q8WY41.html