formin-binding protein 1-like (transducer of Cdc42-dependent actin assembly protein 1, Toca-1)

Function

• coordinates membrane tubulation with reorganization of actin cytoskeleton during endocytosis
• actin polymerization may promote the fission of membrane tubules to form endocytic vesicles
• binds to lipids PIP2 & phosphatidylserine
• promotes membrane invagination & formation of tubules
• promotes CDC42-induced actin polymerization by activating WASL-WASPIP complex
• interacts with GTP-bound CDC42, DAAM1, DIAPH1, DIAPH2, DNM1, DNM2 & WASL/N-WASP

Structure

• belongs to the FNBP1 family
• contains 1 FCH domain
  • contains 1 REM repeat (Hr1 repeat)
  • contains 1 SH3 domain

Compartment

cytoplasm

Alternative splicing

named isoforms=5

More general terms

• formin binding protein

Database

• OMIM: https://mirror.omim.org/entry/608848
• UniProt: http://www.uniprot.org/uniprot/Q5T0N5.html