WAS/WASL-interacting protein family member 1; protein PRPL-2; Wiskott-Aldrich syndrome protein-interacting protein; WASP-interacting protein (WIPF1, WASPIP, WIP)

Function

• may have direct activity on the actin cytoskeleton
• induces actin polymerization & redistribution
• role with NCK1 & GRB2 in recruitment & activation of WASL
• may have role in regulating subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation
• role in intracellular motility of vaccinia virus as an adapter for recruiting WASL to vaccinia virus
• binds to WAS, profilin & actin
• binds to WASL

Structure

• binds to WAS within the N-terminal region 170, at a site distinct from the CDC42-binding site
• belongs to the verprolin family
• contains 1 WH2 domain

Compartment

• cytoplasmic vesicle (putative)
• cytoplasm, cytoskeleton (putative)
• vesicle surfaces & along actin tails
• co-localized with actin stress fibers
• when co-expressed with WASL, no longer associated with actin filaments but accumulated in perinuclear & cortical areas like WASL
• recruited to PIP5K-induced vesicle surfaces in the absence of functional WASL (putative)

Alternative splicing

named isoforms=4

Expression

• highly expressed in peripheral blood mononuclear cells, spleen, placenta, small intestine, colon & thymus
• lower expression in ovary, heart, brain, lung, liver, skeletal muscle, kidney, pancreas, prostate & testis

More general terms

• cytoskeletal protein
• phosphoprotein

Additional terms

• Wiskott-Aldrich syndrome protein (WASp, WAS, IMD2)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=7456
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:7456
• OMIM: https://mirror.omim.org/entry/602357
• UniProt: http://www.uniprot.org/uniprot/O43516.html