FYVE finger-containing phosphoinositide kinase; 1-phosphatidylinositol-4-phosphate 5-kinase; PtdIns(4)P-5-kinase p235 (PIP5K, PIKFYVE)

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Function

  • supports the intracellular PIP pool & to a lesser extent, the PtdIns(4,5)P2 pool
  • generates PIP from PI &, to a lesser extent, PtdIns(4,5)P2 pool from PtdIns4P
  • indications that it phosphorylates the D-5 rather than the D-4 position
  • role in endosome-related membrane trafficking (putative)
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
                    <-->
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Structure

Compartment

Pathology

More general terms

References

Database