FYVE finger-containing phosphoinositide kinase; 1-phosphatidylinositol-4-phosphate 5-kinase; PtdIns(4)P-5-kinase p235 (PIP5K, PIKFYVE)
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Function
- supports the intracellular PIP pool & to a lesser extent, the PtdIns(4,5)P2 pool
- generates PIP from PI &, to a lesser extent, PtdIns(4,5)P2 pool from PtdIns4P
- indications that it phosphorylates the D-5 rather than the D-4 position
- role in endosome-related membrane trafficking (putative)
ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate <--> ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
Structure
- contains 1 DEP domain
- contains 1 FYVE-type Zn+2 finger
- contains 1 PI5K domain
Compartment
- endosome membrane
- mainly associated with membranes of the late endocytic pathway
Pathology
- defects in PIP5K3 are the cause of corneal fleck dystrophy