phosphatidylinositol-4-phosphate 5-kinase type 2 alpha; phosphoinositide-5-kinase 3; PIP5KII-alpha; 1-phosphatidylinositol-4-phosphate 5-kinase 2-alpha; PtdIns(4)P-5-kinase B isoform; diphosphoinositide kinase 2-alpha (PIP5K2A, PIP5K2, PIP4K2A)

Function

• catalyzes the phosphorylation of PtdIns5P to form PtdIns(4,5)P2

ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate
               <-->
ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Structure

• homodimer (putative)
• contains 1 PI5K domain

Expression

• expressed ubiquitously
• high levels in brain
• present in most tissues
• not expressed in skeletal muscle or small intestine

Notes

• previously thought to be a phosphatidylinositol-4-phosphate 5-kinase

More general terms

• phosphoinositide-5-kinase

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5305
• OMIM: https://mirror.omim.org/entry/603140
• UniProt: http://www.uniprot.org/uniprot/P48426.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5305