tumor endothelial marker 5; G protein-coupled receptor 124 (GPR124, TEM5, KIAA1531)

Function

• orphan receptor
• interacts with DLG1

Structure

• binds to DLG1 through its PDZ-binding motif
• belongs to the G-protein coupled receptor 2 family LN-TM7 subfamily
• contains 1 GPS domain
• contains 1 Ig-like (immunoglobulin-like) domain
• contains 5 LRR repeats (leucine-rich repeats)

Compartment

cell membrane; multi-pass membrane protein

Alternative splicing

named isoforms=3

Expression

• expressed in endothelial cells (at protein level)
• abundantly expressed in tumor vessels, heart, placenta, ovary, small intestine, & colon

Notes

• uncertain whether Met-1 or Met-8 is the initiator

More general terms

• G-protein coupled receptor; serpentine receptor
• tumor endothelial marker

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=25960
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:25960
• OMIM: https://mirror.omim.org/entry/606823
• UniProt: http://www.uniprot.org/uniprot/Q96PE1.html