regulator of G-protein signaling 3; RGP3 (RGS3)

Function

• down-regulates signaling from heterotrimeric G-proteins by increasing GTPase activity of G-alpha subunits, thus increasing the amount of inactive GDP-bound form
• down-regulates G-protein-mediated release of inositol phosphates & activation of MAP kinases
• phosphorylated by cyclic GMP-dependent protein kinase
• ISGylated (probable)
• binds EFNB1 & EFNB2 (putative)
• binds the GNB1-GNG2 heterodimer

Structure

• contains 1 C2 domain
• contains 1 PDZ domain (DHR domain)
• contains 1 RGS domain

Compartment

• cytoplasm, nucleus, cell membrane
• long isoforms are cytoplasmic & associated with the plasma membrane
• short isoforms are nuclear

Alternative splicing

named isoforms=6

More general terms

• regulator of G-protein signaling
• phosphoprotein

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5998
• OMIM: https://mirror.omim.org/entry/602189
• UniProt: http://www.uniprot.org/uniprot/P49796.html