GTP-binding regulatory protein beta-1; transducin beta chain 1 (GNB1)

Function

• G-beta & G-gamma chains are required for
  • GTPase activity of heterotrimeric G proteins
  • replacement of GDP by GTP
  • G protein-effector interaction
• interacts with ARHGEF18

Structure

• G proteins are composed of 3 units G-alpha, G-beta & G-gamma
• belongs to the WD repeat G protein beta family
• contains 7 WD repeats

Expression

ubiquitously expressed

More general terms

• GTP-binding regulatory protein beta

Additional terms

• G-beta/gamma
• G-protein

Database

• UniProt: http://www.uniprot.org/uniprot/P62873.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2782
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2782
• OMIM: https://mirror.omim.org/entry/139380