ubiquitin-like modifier-activating enzyme ATG7; ATG12-activating enzyme E1 ATG7; autophagy-related protein 7; autophagy protein 7-like; APG7-like; hAGP7; ubiquitin-activating enzyme E1-like protein (ATG7 APG7L)

Function

• functions as an E1 enzyme essential for multisubstrates such as ATG8-like proteins & ATG12
• forms intermediate conjugates with ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A)
• PE-conjugation to ATG8-like proteins is essential for autophagy
• also acts as an E1 enzyme for ATG12 conjugation to ATG5 & ATG3 (putative)
• interacts with ATG3 & ATG12
  • the complex, composed of ATG3 & ATG7, plays a role in the conjugation of ATG12 to ATG5

Structure

• homodimer (putative)
• the C-terminal part of the protein is essential for the dimerization & interaction with ATG3 & ATG12 (putative)
• belongs to the ATG7 family

Compartment

cytoplasm (probable)

Alternative splicing

named isoforms=2

Expression

• widely expressed
• highest expression in kidney, liver, lymph nodes & bone marrow

More general terms

• acyltransferase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10533
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10533
• OMIM: https://mirror.omim.org/entry/608760
• UniProt: http://www.uniprot.org/uniprot/O95352.html