interleukin-23 receptor (IL23 receptor)

Function

• associates with IL12RB1 to form the IL-23 receptor
• binds IL23 & mediates T-cells, NK cells & possibly certain macrophage/myeloid cells stimulation probably via activation of the Jak-Stat signaling
• IL23 & its receptor IL23R function in innate & adaptive immunity & participate in acute response to infection in peripheral tissues
• interacts with JAK2 & in presence of IL23 with STAT3
• phosphorylated in response to IL23

Structure

• heterodimer with IL12RB1
• contains 2 fibronectin F3 modules

Compartment

cell membrane

Alternative splicing

named isoforms=7

Expression

• expressed by monocytes, Th1, Th0, NK & dendritic cells
• isoform 1 is specifically expressed in NK cells

Pathology

• role in autoimmune inflammatory diseases & tumorigenesis
• genetic variation in IL23R is associated with susceptibility to Crohns disease

More general terms

• interleukin receptor

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1492
• OMIM: https://mirror.omim.org/entry/607562
• OMIM: https://mirror.omim.org/entry/191390
• OMIM: https://mirror.omim.org/entry/266600
• UniProt: http://www.uniprot.org/uniprot/Q5VWK5.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=149233