CD212; interleukin-12 (IL-12) receptor beta-1 chain; IL-12R-beta1; interleukin-12 receptor beta; IL-12 receptor beta component; IL-12RB1 (IL12RB1, IL12R, IL12RB)
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Function
- low affinity interleukin-12 receptor
- associates with IL12RB2 to form a functional, high affinity IL-12 receptor
- involved in IL-12 signal transduction
- associates with IL23R in presence of IL23 to form the IL-23 receptor
Structure
- dimer or oligomer; disulfide-linked
- the WSXWS motif appears to be necessary for proper protein folding, efficient intracellular transport & cell-surface receptor binding
- the box 1 motif is required for JAK interaction &/or activation
- belongs to the type I cytokine receptor family, type 2 subfamily
- contains 5 fibronectin F3 modules
Compartment
membrane
Alternative splicing
named isoforms=2
Pathology
- defects in IL12RB1 are a cause of Mendelian susceptibility to mycobacterial disease
More general terms
Component of
References
- ↑ UniProt http://www.uniprot.org/uniprot/P42701.html
- ↑ IL12RB1base; Note: IL12RB1 mutation db http://bioinf.uta.fi/IL12RB1base/
- ↑ GeneReviews https://www.genecards.org/cgi-bin/carddisp.pl?gene=IL12RB1
- ↑ SeattleSNPs http://pga.gs.washington.edu/data/il12rb1/
- ↑ Altare F et al Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency. Science. 1998 May 29;280(5368):1432-5. PMID: https://www.ncbi.nlm.nih.gov/pubmed/9603732
- ↑ de Jong R et al Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients. Science. 1998 May 29;280(5368):1435-8. PMID: https://www.ncbi.nlm.nih.gov/pubmed/9603733