centaurin-beta-2; Arf-GAP with coiled-coil, ANK repeat & PH domain-containing protein 2; Cnt-b2 (ACAP2, CENTB2, KIAA0041)

Function

• GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6)
• GAP activity stimulated by phosphatidylinositol-4,5-bisphosphate (PIP2) & phosphatidic acid
• phosphorylated upon DNA damage, probably by ATM or ATR

Structure

• contains 3 ANK repeats
• contains 1 Arf-GAP domain
• contains 1 BAR domain
• contains 1 PH domain

Expression

• widely expressed
• highest level in lung

More general terms

• centaurin beta
• ankyrin repeat domain protein (ANKRD)
• phosphoprotein

Additional terms

• pleckstrin homology [PH] domain
• pleckstrin; platelet p47 protein (PLEK P47)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=23527
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:23527
• OMIM: https://mirror.omim.org/entry/607766
• UniProt: http://www.uniprot.org/uniprot/Q15057.html