thymopoietin gamma; lamina-associated polypeptide 2, isoform gamma; thymopoietin, isoform gamma; TP gamma; thymopoietin-related peptide isoform gamma; TPRP isoform gamma; contains: thymopoietin; TP; splenin; TP5 (TMPO, LAP2)

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Function

may help direct assembly of the nuclear lamina & thus help maintain the structural organization of the nuclear envelope
possible receptor for attachment of lamin filaments to the inner nuclear membrane
may be involved in the control of initiation of DNA replication through its interaction with NAKAP95
TP & TP5 may play a role in T-cell development & function
TP5 is an immunomodulating pentapeptide
mitosis-specific phosphorylation specifically abolishes its binding to lamin B & chromosomes (putative)
interacts with LMNB1, LMNB2, BANF1, AKAP8L, GMCL & chromosomes (putative)

as two structurally independent, non-interacting domains:
- LEM-like (also called LAP2-N or LEM-D)
  - LEM-like binds DNA
- LEM (also called LAP2-C or LEM-B)
  - LEM interacts with BANF1
belongs to the LEM family
contains 1 LEM domain
contains 1 LEM-like domain
contains sequence for putative hydrophobic membrane spanning domain from exon 8

TP5 is available under the names Timunox (Cilag), Sintomodulina (Italofarmaco) & Mepentil (Recordati)
used in treatment of primary & secondary immune deficiencies, autoimmunity, infections & cancer