lamin-B2 (LMNB2 LMN2)

Function

• component of the nuclear lamina
• B-type lamins undergo a series of modifications, such as farnesylation & phosphorylation
• increased phosphorylation of the lamins occurs before envelope disintegration & probably plays a role in regulating lamin associations
• interacts with TMEM43 (putative)

Structure

• farnesylated on C-terminal CaaX motif
• belongs to the intermediate filament family

Compartment

• nucleus membrane; lipid-anchor, nucleoplasmic side

Pathology

• defects in LMNB2 are a cause of partial acquired lipodystrophy

More general terms

• lamin-B

Database

• UniProt: http://www.uniprot.org/uniprot/Q03252.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=84823
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:84823
• OMIM: https://mirror.omim.org/entry/150341
• OMIM: https://mirror.omim.org/entry/608709