A-kinase anchor protein 8-like; AKAP8-like protein; helicase A-binding protein 95; HAP95; homologous to AKAP95 protein; HA95; neighbor of A-kinase-anchoring protein 95; neighbor of AKAP95 (AKAP8L, NAKAP, NAKAP95, HRIHFB2018)

Function

• may play a role in constitutive transport element (CTE)-mediated gene expression
• may be involved in nuclear envelope breakdown & chromatin condensation
• may regulate initiation phase of DNA replication when associated with TMPO-beta
• phosphorylated on Ser or Thr possibly by PKA
• interacts with PRPF40A (putative)
• binds to the C-terminal of RNA helicase A & to TMPO-beta
• interacts with RNF43

Structure

belongs to the AKAP95 family

Compartment

• nucleus matrix, cytoplasm
• colocalizes with PRPF40A in the nuclear matrix (putative)
• nuclear at steady state but shuttles between the nucleus & cytoplasm
• associated with the nuclear matrix

Expression

• expressed in the cerebral cortex (at protein level)

More general terms

• zinc finger protein
• nuclear protein
• phosphoprotein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=26993
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:26993
• OMIM: https://mirror.omim.org/entry/609475
• UniProt: http://www.uniprot.org/uniprot/Q9ULX6.html