A-kinase anchor protein 8; AKAP-8; A-kinase anchor protein 95 kD; AKAP 95 (AKAP8, AKAP95)

Function

• anchoring protein that mediates the subcellular compartmentation of cAMP-dependent protein kinase (PKA type II)
• binds to dimeric RII-alpha regulatory subunit of PKA during mitosis
• interacts (via C-terminus) with FIGN

Structure

belongs to the AKAP95 family

Compartment

• nucleus matrix
• associated with the nuclear matrix
• redistributed & detached from condensed chromatin during mitosis

Expression

• highly expressed in heart, liver, skeletal muscle, kidney & pancreas

More general terms

• A-kinase anchor protein
• nuclear protein
• zinc finger protein
• phosphoprotein

Additional terms

• protein kinase A

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10270
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:10270
• OMIM: https://mirror.omim.org/entry/604692
• UniProt: http://www.uniprot.org/uniprot/O43823.html