NSAID gastropathy

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Etiology

* controversial

Epidemiology

Pathology

Clinical manifestations

* 20% of patients taking NSAIDs long-term will have endoscopic evidence of gastric or duodenal ulceration

Management

* one study found famotidine effective in prevention of both duodenal & gastric ulcers in patients on long-term NSAID therapy

More general terms

Additional terms

References

  1. Jump up to: 1.0 1.1 1.2 1.3 Medical Knowledge Self Assessment Program (MKSAP) 11, 15, 16, 17. American College of Physicians, Philadelphia 1998, 2009, 2012, 2015
  2. Jump up to: 2.0 2.1 2.2 UCLA Intensive Course in Geriatric Medicine & Board Review, Marina Del Ray, CA, Sept 12-15, 2001
  3. Jump up to: 3.0 3.1 Scheiman JM et al, Prevention of ulcers by esomeprazole in at-risk patients using non-selective NSAIDs and COX-2 inhibitors Am J Gastroenterol 2006; 1-1:701 PMID: https://www.ncbi.nlm.nih.gov/pubmed/16494585
  4. Jump up to: 4.0 4.1 Luo J-C et al. Randomised clinical trial: Rabeprazole plus aspirin is not inferior to rabeprazole plus clopidogrel for the healing of aspirin-related peptic ulcer. Aliment Pharmacol Ther 2011 Sep; 34:519 PMID: https://www.ncbi.nlm.nih.gov/pubmed/21726257
  5. Jump up to: 5.0 5.1 5.2 Lanza FL, Chan FK, Quigley EM; Practice Parameters Committee of the American College of Gastroenterology. Guidelines for prevention of NSAID-related ulcer complications. Am J Gastroenterol. 2009 Mar;104(3):728-38 PMID: https://www.ncbi.nlm.nih.gov/pubmed/19240698