depression in patients with substance abuse

^[1]^[2]^[3]

Pathology

transient depression may resolve with abstinence from substance abuse
6 trials show no benefit in treating depression in patients enrolled in substance abuse treatment programs
alcoholics with depression may benefit from combination treatment with:
a healthy diet consisting of more fish, fruits, vegetables, whole grains associated less depression

↑ Journal Watch 24(11):87, 2004 Nunes EV, Levin FR. Treatment of depression in patients with alcohol or other drug dependence: a meta-analysis. JAMA. 2004 Apr 21;291(15):1887-96. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15100209
↑ ^2.0 ^2.1 Pettinati HM et al. A double-blind, placebo-controlled trial combining sertraline and naltrexone for treating co-occurring depression and alcohol dependence. Am J Psychiatry 2010 Mar 15; [e-pub ahead of print] <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/20231324 <Internet> http://dx.doi.org/10.1176/appi.ajp.2009.08060852
↑ ^3.0 ^3.1 Joffe A Does a Healthy Diet Protect Against Depression in Adolescence? NEJM Journal Watch. Jan 26, 2018 Massachusetts Medical Society (subscription needed) http://www.jwatch.org
Oddy WH, Allen KL, Trapp GSA et al. Dietary patterns, body mass index and inflammation: Pathways to depression and mental health problems in adolescents. Brain Behav Immun 2018 Jan 12; PMID: https://www.ncbi.nlm.nih.gov/pubmed/29339318 https://www.sciencedirect.com/science/article/pii/S0889159118300023