Brugada syndrome

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Introduction

syncope in the context of a family history of sudden cardiac death

Brugada syndrome was originally described in 1992.

Epidemiology

Genetics

Clinical manifestations

Diagnostic criteria

plus one of the following:

Diagnostic procedures

* electrocardiogram plus 1 or more clinical manifestations (or complications) makes diagnosis

# benign early repolarization generally has a positive T-wave

Complications

Management

More general terms

More specific terms

Additional terms

References

  1. Antzelevitch C. The Brugada syndrome. J Cardiovasc Electrophysiol. 1998 May;9(5):513-6. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/9607460
  2. Chen Q, Kirsch GE, Zhang D, Brugada R, Brugada J, Brugada P, Potenza D, Moya A, Borggrefe M, Breithardt G, Ortiz-Lopez R, Wang Z, Antzelevitch C, O'Brien RE, Schulze-Bahr E, Keating MT, Towbin JA, Wang Q. Genetic basis and molecular mechanism for idiopathic ventricular fibrillation. Nature. 1998 Mar 19;392(6673):293-6. PMID: https://www.ncbi.nlm.nih.gov/pubmed/9521325
  3. Gussak I, Antzelevitch C, Bjerregaard P, Towbin JA, Chaitman BR. The Brugada syndrome: clinical, electrophysiologic and genetic aspects. J Am Coll Cardiol. 1999 Jan;33(1):5-15. Review. PMID: https://www.ncbi.nlm.nih.gov/pubmed/9935001
  4. Medical Knowledge Self Assessment Program (MKSAP) 16, 17. American College of Physicians, Philadelphia 2012, 2015
  5. Mizusawa Y, Wilde AA. Brugada syndrome. Circ Arrhythm Electrophysiol. 2012 Jun 1;5(3):606-16 PMID: https://www.ncbi.nlm.nih.gov/pubmed/22715240
  6. 6.0 6.1 6.2 6.3 DeFilippis EM, Vaidya A, Braun D et al A Shocking Turn of Events N Engl J Med. 2018 May 24;378(21):e29. PMID: https://www.ncbi.nlm.nih.gov/pubmed/29791827 https://www.nejm.org/doi/full/10.1056/NEJMimc1710576

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