paroxysmal familial ventricular fibrillation; idiopathic ventricular fibrillation

Etiology

• 5-12% of cases idiopathic

Epidemiology

• may cause > 300,000 sudden deaths each year in USA

Genetics

• associated with mutations in SCN5A gene

Clinical manifestations

• fibrillation induced by stressful emotional stimuli, but not exercise

Diagnostic procedures

• EKG: short PR interval, prominent gamma wave

More general terms

• ventricular fibrillation (V Fib)
• genetic disease of the heart

Additional terms

• Na+ channel protein type 5 subunit alpha; Na+ channel protein type V subunit alpha; voltage-gated Na+ channel subunit alpha Nav1.5; Na+ channel protein cardiac muscle subunit alpha; HH1 (SCN5A)

Database

• OMIM: https://mirror.omim.org/entry/603829