cancer surgery
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Indications
- malignant neoplasm susceptible to resection
Procedure
- care take to prevent seeding of metastases
- mass spectrometry-assisted surgery[2] (intelligent knife)
- handheld diathermy device is applied to tissue to create a small 'surgical aerosol' of compounds that is transferred through a suction tube to a mass spectrometer
- the mass spectrometry patterns (particularly lipid metabolite analysis) distinguish different types of tissue with 100% sensitivity & specificity[2]
Complications
- relative risk of cancer deaths exceeds that of noncancer deaths for older adults after cancer surgery[3]
- no increase in risk of noncancer death early after cancer surgery[3]
Comparative biology
- inflammation during wound healing after surgery may disrupt ability of T-cells to keep metastasing tumor cells in check
- anti-inflammatory treatment reduces metastasis in mice[1]
Notes
- no benefit of perioperative palliative care surgical for newly diagnosed cancer patients scheduled for curative surgery[4]
- perioperative palliative care may be better reserved for frail elderly
More general terms
References
- ↑ 1.0 1.1 Krall JA, Reinhardt F, Mercury OA et al. The systemic response to surgery triggers the outgrowth of distant immune-controlled tumors in mouse models of dormancy. Sci Transl Med 2018 Apr 11; 10:3464. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/29643230 <Internet> http://stm.sciencemag.org/content/10/436/eaan3464
- ↑ 2.0 2.1 2.2 Tzafetas M, Mitra A, Paraskevaidi M et al. The intelligent knife (iKnife) and its intraoperative diagnostic advantage for the treatment of cervical disease. Proc Natl Acad Sci U S A 2020 Mar 31; 117:7338 PMID: https://www.ncbi.nlm.nih.gov/pubmed/32179675 Free PMC Article https://www.pnas.org/content/117/13/7338
- ↑ 3.0 3.1 3.2 Chesney TR, Coburn N, Mahar AL et al All-Cause and Cancer-Specific Death of Older Adults Following Surgery for Cancer. JAMA Surg. 2021;156(7):e211425 PMID: https://www.ncbi.nlm.nih.gov/pubmed/33978695 PMCID: PMC8117065 (available on 2022-05-12) https://jamanetwork.com/journals/jamasurgery/fullarticle/2779970
- ↑ 4.0 4.1 Aslakson RA, Rickerson E, Fahy B et al Effect of Perioperative Palliative Care on Health-Related Quality of Life Among Patients Undergoing Surgery for Cancer. A Randomized Clinical Trial. JAMA Netw Open. 2023;6(5):e2314660. PMID: https://www.ncbi.nlm.nih.gov/pubmed/37256623 https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2805450
Haas B, Rubenfeld GD Early Palliative Care Consultation Before High-risk Surgery. JAMA Netw Open. 2023;6(5):e2314627. PMID: https://www.ncbi.nlm.nih.gov/pubmed/37256628 https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2805455