GATA2 deficiency

Etiology

• haploinsufficiency of the hematopoietic transcription factor GATA2

Epidemiology

• congenital or adult-onset

Pathology

• monocytopenia
• mycobacterial infections
• dendritic cell, monocyte, B, & natural killer deficiency
• familial myelodysplastic syndrome &/or acute myeloid leukemia
  • Emberger syndrome

More general terms

• cellular immune dysfunction

Additional terms

• GATA binding factor-2; endothelial transcription factor GATA-2 (GATA2)