GATA binding factor-2; endothelial transcription factor GATA-2 (GATA2)

Function

• transcriptional activator
• regulates endothelin-1 gene expression in endothelial cells
• binds to the consensus sequence 5'-AGATAG-3'

Structure

contains 2 GATA-type Zn+2 fingers

Compartment

nucleus

Expression

endothelial cells

Pathology

• haploinsufficiency of GATA2 results in GATA2 deficiency

More general terms

• GATA binding factor (transcription factor GATA)

Database

• OMIM: https://mirror.omim.org/entry/137295
• UniProt: http://www.uniprot.org/uniprot/P23769.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=2624