cellular immune dysfunction

Etiology

• diseases (group 1 pathogens)
  • acute & chronic lymphocytic leukemia
  • lymphoma
    • Hodgkin's disease
    • non-Hodgkin's lymphoma
  • thymus hypoplasia or aplasia
  • sarcoidosis
  • lepromatous leprosy
• acquired immunodeficiency syndrome (AIDS)
• inherited disorders
  • purine nucleoside phosphorylase deficiency
  • primary T-cell immunodeficiency
• organ transplantation
• pharmaceutical agents: (immunosuppressants)
  • cyclosporine
  • tacrolimus (FK506)
  • mycophenolate
  • mofetil
  • azathioprine
  • corticosteroids

Pathology

Pathogens

• group 1 (above)
  • Listeria monocytogenes
  • Mycobacterium species
  • Candida species
  • Aspergillus species
  • Cryptococcus neoformans
  • Herpes simplex virus
  • varicella-zoster virus
• acquired immunodeficiency syndrome (AIDS)
  • Pneumocystis carinii
  • cytomegalovirus
  • Herpes simplex
  • Mycobacterium avium intracellulare (MAI)
  • Cryptococcus neoformans
  • Candida species
  • also see acquired immunodeficiency syndrome (AIDS)
• purine nucleoside phosphorylase deficiency
  • fungi
  • viruses

Diagnostic procedures

• skin test response to PPD, mumps, Candida antigens is deficient

More general terms

• immunodeficiency; immunodeficiency syndrome

More specific terms

• Acquired Immuno-Deficiency Syndrome (HIV infection stage 3, AIDS)
• CD4 T lymphocyte deficiency disorder (HIV-negative AIDS)
• Chediak-Higashi syndrome
• chronic granulomatous disease
• chronic mucocutaneous candidiasis
• GATA2 deficiency
• neutrophil immunodeficiency syndrome
• primary T-cell immunodeficiency

Additional terms

• Acquired Immuno-Deficiency Syndrome (HIV infection stage 3, AIDS)
• cellular immunity
• immunosuppressive agent
• mixed cellular & humoral immune dysfunction