inflammatory breast cancer; mastitis carcinomatosa
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Pathology
- aggressive, rapidly progressive cancer
- lymphatic obstruction due to invasive breast adenocarcinoma
- edema, inflammation
- dermal-lymphatic infiltration
- despite name, not associated with inflammatory infiltrate[3]
Clinical manifestations
- erythema, edema & thickening of the breast skin (may have the appearance of an orange peel, peau d'orange)
- pruritus, pain, tenderness, warmth
- no fever
- nipple retraction can occur
- in most cases a distinct breast mass not felt
Diagnostic criteria
- based upon clinical appearance[1]
Laboratory
Diagnostic procedures
- breast biopsy of inflammed tissue
Radiology
- not diagnostic, part of staging for breast cancer
- CT of abdomen & thorax
- bone scan[1]
Complications
- high risk for metastases[1]
Differential diagnosis
Management
- neoadjuvant chemotherapy or endocrine therapy, mastectomy & adjuvant radiation therapy[1]
More general terms
References
- ↑ 1.0 1.1 1.2 1.3 1.4 Medical Knowledge Self Assessment Program (MKSAP) 17, 18, 19. American College of Physicians, Philadelphia 2015, 2018, 2021.
Medical Knowledge Self Assessment Program (MKSAP) 19 Board Basics. An Enhancement to MKSAP19. American College of Physicians, Philadelphia 2022 - ↑ Chia S, Swain SM, Byrd DR, Mankoff DA. Locally advanced and inflammatory breast cancer. J Clin Oncol. 2008 Feb 10;26(5):786-90 PMID: https://www.ncbi.nlm.nih.gov/pubmed/18258987
- ↑ 3.0 3.1 WHO Classification of Tumors of the Breast and Female Genital Organs. Editors: Tavassoli FA, Devilee P IARC Press, 2003
- ↑ NEJM Knowledge+ Question of the Week. Sept 11, 2018 https://knowledgeplus.nejm.org/question-of-week/945/
- ↑ Dushkin H, Cristofanilli M. Inflammatory breast cancer. J Natl Compr Canc Netw 2011 Feb 12; 9:233 PMID: https://www.ncbi.nlm.nih.gov/pubmed/21310844