axonogenesis; axon guidance; axon pathfinding

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Function

RAB10 may regulate vesicular membrane trafficking toward the axonal plasma membrane
axons have growth cones at the tip
the growth cones contain receptors that recognize guidance cues
netrins are secreted molecules that can act to attract or repel axons by binding to their receptors, DCC & UNC5.
Slits (Sli) are secreted proteins that normally repel growth cones by engaging Robo
ephrins are cell surface molecules that activate Eph receptors on the surface of other cells
- interaction can be attractive or repulsive
- ephrins can also act as receptors by transducing a signal into the expressing cell, while Ephs act as the ligands (bi-directional signaling)
semaphorins are primarily axonal repellents that activate complexes of cell-surface receptors called plexins & neuropilins
cell adhesion molecules (CAMs) mediate adhesion between growing axons & elicit intracellular signalling within the growth cone
- IgSF-CAMs & cadherins