rab10 proto-oncogene protein
Jump to navigation
Jump to search
Function
- transport of proteins from Golgi to plasma membrane
- roles in vesicular trafficking & neurotransmitter release
- role in asymmetric protein transport to the plasma membrane within the polarized neurons & epithelial cells
- role in axonogenesis through regulation of vesicular membrane trafficking toward the axonal plasma membrane
- in epithelial cells, regulates transport from the Golgi to the basolateral membrane
- may play a role in the basolateral recycling pathway & in phagosome maturation
- activated by the DENND4C guanine exchange factor
- inactivation via hydrolysis of bound GTP is catalyzed by GTPase activating protein
- may regulate delivery of SLC2A4/GLUT4 glucose transporter- enriched vesicles to plasma membrane
- may regulate transport of TLR4 to plasma membrane
- interacts with MYO5A, GDI1 & maybe with GDI2
- interaction (GDP-bound form) with LLGL1 promotes RAB10 association with membranes & activation through competition with the Rab inhibitor GDI1 (putative)
- interacts with EXOC4
- associates with the exocyst (putative)
- interacts (GTP-bound form) with MICALCL, MICAL1, MICAL3, EHBP1 & EHBP1L1
- interacts with TBC1D13 (putative)
Structure
Compartment
- cell membrane; lipid-anchor; cytoplasmic side (putative)
- Golgi, endoplasmic reticulum
- localizes to endoplasmic reticulum at domains of new tubule growth
- associates with SLC2A4/GLUT4 storage vesicles
- localizes to base of cilium
- transiently associates with phagosomes (putative)
Genetics
- RAB10 variants modify risk for Alzheimer's disease[5]
- knockdown of RAB10 decreases Abeta42 & Abeta42/Abeta40 in neuroblastoma cells
- RAB10 expression is elevated in brain of patients with Alzheimer's disease
- Rs142787485 in RAB10 confers protection against Alzheimer's disease[5]
More general terms
References
- ↑ Kahn RA, Der CJ, Bokoch GM. The ras superfamily of GTP-binding proteins: guidelines on nomenclature. FASEB J. 1992 May;6(8):2512-3. PMID: https://www.ncbi.nlm.nih.gov/pubmed/1592203
- ↑ Seabra MC et al Rab GTPases, intracellular traffic and disease Trends in Molecular Medicine 8:23, 2002 PMID: https://www.ncbi.nlm.nih.gov/pubmed/11796263
- ↑ Entrez Gene http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=10890
- ↑ UniProt http://www.uniprot.org/uniprot/P61026.html
- ↑ 5.0 5.1 5.2 Ridge PG, Karch CM, Hsu S et al Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience. Genome Medicine. Nov 29 2017 PMID: https://www.ncbi.nlm.nih.gov/pubmed/29183403 Free PMC Article
- ↑ English AR, Voeltz GK. Rab10 GTPase regulates ER dynamics and morphology. Nat Cell Biol. 2013 Feb;15(2):169-78. Epub 2012 Dec 23. PMID: https://www.ncbi.nlm.nih.gov/pubmed/23263280 Free PMC Article
- ↑ Chen Y, Wang Y, Zhang J et al Rab10 and myosin-Va mediate insulin-stimulated GLUT4 storage vesicle translocation in adipocytes. J Cell Biol. 2012 Aug 20;198(4):545-60 PMID: https://www.ncbi.nlm.nih.gov/pubmed/22908308 Free PMC Article
- ↑ Yoshimura S, Gerondopoulos A, Linford A, Rigden DJ, Barr FA. Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. J Cell Biol. 2010 Oct 18;191(2):367-81. Epub 2010 Oct 11. PMID: https://www.ncbi.nlm.nih.gov/pubmed/20937701 Free PMC Article
- ↑ Babbey CM, Ahktar N, Wang E, Chen CC, Grant BD, Dunn KW. Rab10 regulates membrane transport through early endosomes of polarized Madin-Darby canine kidney cells. Mol Biol Cell. 2006 Jul;17(7):3156-75. Epub 2006 Apr 26. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16641372 Free PMC Article