N,N-dimethyl-3-methylbenzamide (DEET, Ultrathon)

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[1][2][3][4]

Pharmacology

Tradenames: Off, Repel, Cutter

Indications

mosquito repellent (best on market 2002)

Dosage

  • apply to skin & clothes[2]
  • 10-50% most adults[2]
  • 10% for children[2]
    • BID 6 months-2 years
    • TID > 2 years of age
  • up to 30% for children QD > 2 months of age[3]

Ultrathon: polymer form contains 25% DEET, lasts up to 8 hours

Avoid DEET/sunscreen combinations, sunscreen needs more frequent application

  • mean protection until time of 1st bite 
    concentration    minutes until 1st bite (mean of 15)

         24%            302
         20%            234
        6.6%            112
        4.8%             88

Adverse effects

  • excellent safety record after 40 years of use
  • excessive use associated with neurotoxicity[2]
    • limit concentration in children (see dosage)

More general terms

References

  1. ↑ Journal Watch 22(15):116, 2002 Fradin MS & Day JF N Engl J Meed 347:13, 2002
  2. ↑ 2.0 2.1 2.2 2.3 2.4 Prescriber's Letter 10(7):40 2003 Keeping Safe From West Nile Virus Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=190709&pb=PRL (subscription needed) http://www.prescribersletter.com
  3. ↑ 3.0 3.1 Prescriber's Letter 10(9):53 2003 Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=190911&pb=PRL (subscription needed) http://www.prescribersletter.com
  4. ↑ Prescriber's Letter 12(6): 2005 Keeping Safe From West Nile Virus Detail-Document#: http://prescribersletter.com/(5bhgn1a4ni4cyp2tvybwfh55)/pl/ArticleDD.aspx?li=1&st=1&cs=&s=PRL&pt=3&fpt=25&dd=210601&pb=PRL (subscription needed) http://www.prescribersletter.com

Database

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