diagnostic criteria for sepsis

Diagnostic criteria

• infection or suspected infection & some of the following
• general
  • fever > 38.3 C
  • hypothermia: core temperature < 36.0 C
  • heart rate > 90
  • tachypnea
  • altered mental status
  • edema or positive fluid balance (> 20 mL/kg over 24 hours)
  • hyperglycemia (plasma glucose > 140 mg/dL) in absence of diabetes mellitus
• inflammation
  • leukocytosis: leukocyte count > 12,000/uL
  • leukopenia: leukocyte count < 4000/uL
  • > 10% immature leukocytes
  • elevated serum C-reactive protein
  • elevated serum procalcitonin
• hemodynamic instability
  • arterial hypotension
    • systolic BP < 90 mm Hg
    • mean arterial pressure < 70 mmg Hg
• organ dysfunction
  • arterial hypoxemia: PaO2/FiO2 < 300 mm Hg
  • acute oliguria: urine output < 0.5 mg/kg over 2 hours despite adequate hydration
  • serum creatinine increase of > 0.5 mg/dL
  • INR > 1.5 or aPTT > 60 seconds
  • ileus
  • thrombocytopenia: platelet count < 100,000/uL
  • hyperbilirubinemia: serum total bilirubin > 4 mg/dL
• inadequate tissue perfusion
  • increased plasma lactate (> 1 mmol/L)
  • decreased capillary refill
  • mottling

More general terms

• criteria