circulating plasma factors in cellular senescence
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Introduction
Includes:
Clinical significance
- circulating plasma factors that play a role in cellular senescence represent a potentially modifiable target for treating human aging & age-associated disease
Comparative biology
- muscle stem cells (satellite cells) from aged mice tend to convert from a myogenic to fibrogenic lineage as they begin to proliferate & this conversion is mediated by the systemic environment of the old animals via Wnt signaling
- p16ink4A silencing by RNA interference restores regenerative capacity of satellite cells in old mice (see age-associated changes in skeletal muscle)