circulating plasma factors in cellular senescence

Introduction

Includes:

• klotho peptide

Clinical significance

• circulating plasma factors that play a role in cellular senescence represent a potentially modifiable target for treating human aging & age-associated disease
• muscle stem cells (satellite cells) from aged mice tend to convert from a myogenic to fibrogenic lineage as they begin to proliferate & this conversion is mediated by the systemic environment of the old animals via Wnt signaling
• p16ink4A silencing by RNA interference restores regenerative capacity of satellite cells in old mice (see age-associated changes in skeletal muscle)

Additional terms

• aging