myogenic satellite cell
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Introduction
Cells the may differentiate into myocytes. Muscle fibers regenerate by recruitment of satellite cells.
Pathology
(see age-associated changes in skeletal muscle)
- adult skeletal muscle regenerates throughout life, but as the muscle ages, its ability to repair diminishes & eventually fails[1]
- impairment is associated with an increase in tissue fibrosis[2]
- muscle stem cells (satellite cells) from aged mice tend to convert from a myogenic to a fibrogenic lineage as they begin to proliferate & this conversion is mediated by factors in the systemic environment of the old animals
- heterochronic parabioses, exposing old mice to factors present in young serum restores regenerative capacity of aged satellite cells[2]
More general terms
Additional terms
References
- ↑ 1.0 1.1 Carlson ME, Hsu M, Conboy IM. Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells. Nature. 2008 Jul 24;454(7203):528-32 PMID: https://www.ncbi.nlm.nih.gov/pubmed/18552838
- ↑ 2.0 2.1 2.2 Brack AS et al, Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis. Science. 2007 Aug 10;317(5839):807-10. PMID: https://www.ncbi.nlm.nih.gov/pubmed/17690295
- ↑ Conboy IM et al, Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature. 2005 Feb 17;433(7027):760-4. PMID: https://www.ncbi.nlm.nih.gov/pubmed/15716955