RNA interference; clustered regularly interspaced short palindromic repeats (CRISPR)
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Indications
Principle
- siRNA may be used to selectively turn off translation of specific proteins
Clinical significance
- used to identify proteins responsible for resistance to monoclonal antibody therapy for melanoma
Notes
More general terms
Additional terms
- CRISPR; clustered regularly interspaced short palindromic repeats
- gene editing
- short interfering double-stranded RNA (siRNA, microRNA, miRNA)
References
- ↑ 1.0 1.1 Wang T et al. Genetic screens in human cells using the CRISPR-Cas9 system. Science 2014 Jan 3; 343:80 <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/24336569 <Internet> http://www.sciencemag.org/content/343/6166/80
Shalem O et al. Genome-scale CRISPR-Cas9 knockout screening in human cells. Science 2014 Jan 3; 343:84. <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/24336571 <Internet> http://www.sciencemag.org/content/343/6166/84 - ↑ Niu Y et al. Generation of gene-modified cynomolgus monkey via Cas9/RNA- mediated gene targeting in one-cell embryos. Cell 2014 Jan 30; <PubMed> PMID: https://www.ncbi.nlm.nih.gov/pubmed/24486104 <Internet> http://www.cell.com/retrieve/pii/S0092867414000798
Pennisi E. Transgenic animals. Editing of targeted genes proved possible in monkeys. Science 2014 Jan 31; 343:476 PMID: https://www.ncbi.nlm.nih.gov/pubmed/24482459