macroamylasemia

Etiology

• protein-bound amylase
  • inborn macroamylasemia: attachment to albumin or globulin
  • IgA-bound:
    • celiac disease
    • lymphoma
    • immunoproliferative small bowel disease
  • IgG-bound:
    • chronic infection
    • liver disease
  • immune complex-bound:
    • AIDS
    • connective tissue disease
    • Sjogren's disease

Epidemiology

• 2% of normal persons

Pathology

• pancreatic amylase & salivary amylase present in variable proprotions

Laboratory

• the amylase-protein complex may intermittently dissociate resulting in fluctuating serum amylase levels from normal to grossly elevated
• urine amylase is normal

More general terms

• sign/symptom

Additional terms

• amylase
• amylase in serum/plasma
• amylase in urine
• hyperamylasemia
• macroamylase