amylase-1 (salivary amylase, 1,4-alpha-D-glucan glucanohydrolase 1,salivary alpha-amylase, AMY1)

Function

• endohydrolysis of 1,4-alpha-D-glucosidic linkages in oligosaccharides & polysaccharides

Cofactor:

• binds 1 Ca+2 per subunit
• binds 1 Cl- per subunit

Structure

• monomer
• belongs to the glycosyl hydrolase 13 family

Compartment

secreted

Laboratory

• amylase salivary in serum

Notes

• recently duplicated genes AMY1A, AMY1B, & AMY1C show no differences over a region of 950 base pairs sequenced; thus sequences of the amylase 1A, amylase 1B & amylase 1C proteins may be identical

More general terms

• alpha amylase

More specific terms

• amylase-1A; 1,4-alpha-D-glucan glucanohydrolase 1; salivary alpha-amylase (AMY1A, AMY1)
• amylase-1B (salivary)
• amylase-1C (salivary)

Database

• OMIM: https://mirror.omim.org/entry/104700
• OMIM: https://mirror.omim.org/entry/104701
• OMIM: https://mirror.omim.org/entry/104702
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=276