coordinator of PRMT5 & differentiation stimulator; cooperator of PRMT5; protein TTP1 (COPRS, C17orf79, COPR5)

Function

• histone-binding protein
• required for histone H4 methyltransferase activity of PRMT5
  • specifically required for histone H4 Arg-3 methylation mediated by PRMT5
  • not required for histone H3 Arg-8 methylation
  • likely modulates substrate specificity of PRMT5
• specifically interacts with the N-terminus of histone H4, but not with histone H3, suggesting that it acts by promoting the association between histone H4 & PRMT5
• role in CCNE1 promoter repression
• role in muscle cell differentiation
  • modulates recruitment of PRMT5 to promoterd of genes involved in coordination between cell cycle exit & muscle differentiation (putative)
• interacts with PRMT5
• interacts with histone H4
• specifically interacts with the N-terminus of histone H4 but not with histone H3
• interacts with CBFB (putative)
• found in a complex with PRMT5, RUNX1 & CBFB (putative)

Compartment

nucleus

More general terms

• nuclear protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=55352
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:55352
• UniProt: http://www.uniprot.org/uniprot/Q9NQ92.html