prednisolone/sulfacetamide (Blephamide, Cetapred, Metimyd)

Introduction

Tradenames: Blephamide, Cetapred, Metimyd.

Indications

• inflammatory ocular condition with risk of infection
• eyelid disease
• may also be used as on otic solution

Contraindications

sulfa allergy

Dosage

• suspension: instil 1-3 drops every 2-3 hours while awake
• ointment: apply QD-QID

Blephamide: (ophthalmic)

• sodium sulfacetamide 10%/prednisolone acetic_acid 0.2% (3.5 g [ointment], 5 mL, 10 mL [solution])

Cetapred: (ophthalmic)

• sodium sulfacetamide 10%/prednisolone acetic_acid 0.25% (3.5 g [ointment])

Adverse effects

(ophthalmic)

• not common (1-10%)
  • local burning, stinging, irritation
• uncommon (< 1%)
  • vertigo, seizures, psychosis, pseudotumor cerebri, headache, Stevens-Johnson syndrome, skin atrophy, Cushing's syndrome, pituitary-adrenal axis suppression, peptic ulcer, nausea/vomiting, muscle weakness, osteoporosis, fractures, cataracts, glaucoma

Mechanism of action

• antibiotic/steroid combination

More general terms

• pharmacologic combination

Components

• sulfacetamide (Sulfacet)
• prednisolone; deltahydrocortisone; metacortandralone (Pred Forte, AK-Pred, Inflamase, Pediapred, Pred Mild, Prelone, Flo-Pred, Veripred 20)